| 1 | Toy Story 3 (Disney) | $415,004,880 | |
| Jun 18 |
| 2 | Alice in Wonderland (2010) (Disney) | $334,191,110 |
|
| Mar 05 |
| 3 | Iron Man 2 (Paramount) | $312,128,345 | |
| May 07 |
| 4 | The Twilight Saga: Eclipse (Summit) | $300,531,751 |
|
| Jun 30 |
| 5 | Harry Potter and the Deathly Hallows: Part I (Warner Bros.) | $294,856,409 |
|
| Nov 19 |
| 6 | Inception (Warner Bros.) | $292,576,195 |
|
| Jul 16 |
| 7 | Despicable Me (Universal) | $251,513,985 |
|
| Jul 09 |
| 8 | Shrek Forever After (Paramount / DreamWorks) | $238,395,990 |
|
| May 21 |
| 9 | How to Train Your Dragon (Paramount / DreamWorks) | $217,581,231 |
|
| Mar 26 |
| 10 | Tangled (Disney) | $197,975,575 |
|
| Nov 24 |
| 11 | The Karate Kid (2010) (Sony / Columbia) | $176,591,618 |
|
| Jun 11 |
| 12 | TRON: Legacy (Disney) | $171,820,225 |
|
| Dec 17 |
| 13 | True Grit (2010) (Paramount) | $169,876,610 |
|
| Dec 22 |
| 14 | Clash of the Titans (2010) (Warner Bros.) | $163,214,888 |
|
| Apr 02 |
| 15 | Grown Ups (Sony / Columbia) | $162,001,186 |
|
| Jun 25 |
| 16 | Little Fockers (Universal) | $148,438,600 |
|
| Dec 22 |
| 17 | Megamind (Paramount / DreamWorks) | $148,415,853 |
|
| Nov 05 |
| 18 | The King's Speech (Weinstein Company) | $133,293,611 |
|
| Nov 26 |
| 19 | The Last Airbender (Paramount) | $131,601,062 |
|
| Jul 01 |
| 20 | Shutter Island (Paramount) | $128,012,934 |
|
| Feb 19 |
| 21 | The Other Guys (Sony / Columbia) | $119,219,978 |
|
| Aug 06 |
| 22 | Salt (Sony / Columbia) | $118,311,368 |
|
| Jul 23 |
| 23 | Jackass 3D (Paramount) | $117,229,692 |
|
| Oct 15 |
| 24 | Valentine's Day (Warner Bros. / New Line) | $110,486,000 |
|
| Feb 12 |
| 25 | Black Swan (Fox Searchlight) | $106,394,069 |
|
| Dec 03 |
| 26 | Robin Hood (Universal) | $105,269,730 |
|
| May 14 |
| 27 | The Chronicles of Narnia: The Voyage of the Dawn Treader (Fox) | $104,247,474 |
|
| Dec 10 |
| 28 | The Expendables (Lionsgate) | $103,068,524 |
|
| Aug 13 |
| 29 | Due Date (Warner Bros.) | $100,539,043 |
|
| Nov 05 |
| 30 | Yogi Bear (Warner Bros.) | $99,549,375 |
|
| Dec 17 |
| 31 | Date Night (Fox) | $98,711,404 |
|
| Apr 09 |
| 32 | The Social Network (Sony / Columbia) | $96,962,694 |
|
| Oct 01 |
| 33 | Sex and the City 2 (Warner Bros. / New Line) | $95,347,692 |
|
| May 27 |
| 34 | The Book of Eli (Warner Bros.) | $94,835,000 |
|
| Jan 15 |
| 35 | The Fighter (Paramount) | $93,461,485 |
|
| Dec 10 |
| 36 | The Town (Warner Bros.) | $92,186,262 |
|
| Sep 17 |
| 37 | Prince of Persia: The Sands of Time (Disney) | $90,759,676 |
|
| May 28 |
| 38 | Red (2010) (Summit) | $90,380,162 |
|
| Oct 15 |
| 39 | Percy Jackson and the Olympians: The Lightning Thief (Fox) | $88,761,720 |
|
| Feb 12 |
| 40 | Paranormal Activity 2 (Paramount) | $84,752,907 |
|
| Oct 22 |
| 41 | Unstoppable (2010) (Fox) | $81,562,942 |
|
| Nov 12 |
| 42 | Eat Pray Love (Sony / Columbia) | $80,574,010 |
|
| Aug 13 |
| 43 | Dear John (Sony / Screen Gems) | $80,014,521 |
|
| Feb 05 |
| 44 | The A-Team (Fox) | $77,222,099 |
|
| Jun 11 |
| 45 | Knight and Day (Fox) | $76,423,035 |
|
| Jun 23 |
| 46 | Dinner for Schmucks (Paramount / DreamWorks) | $73,026,337 |
|
| Jul 30 |
| 47 | The Tourist (Sony / Columbia) | $67,631,157 |
|
| Dec 10 |
| 48 | The Bounty Hunter (Sony / Columbia) | $67,061,228 |
|
| Mar 19 |
| 49 | Diary of a Wimpy Kid (Fox) | $64,003,625 |
|
| Mar 19 |
| 50 | The Sorcerer's Apprentice (Disney) | $63,150,991 |
|
| Jul 14 |
| 51 | A Nightmare on Elm Street (2010) (Warner Bros. / New Line) | $63,075,011 |
|
| Apr 30 |
| 52 | The Last Song (Disney) | $62,950,384 |
|
| Mar 31 |
| 53 | The Wolfman (Universal) | $61,979,680 |
|
| Feb 12 |
| 54 | Get Him to the Greek (Universal) | $60,974,475 |
|
| Jun 04 |
| 55 | Resident Evil: Afterlife (Sony / Screen Gems) | $60,128,566 |
|
| Sep 10 |
| 56 | Tyler Perry's Why Did I Get Married Too? (Lionsgate) | $60,095,852 |
|
| Apr 02 |
| 57 | The Tooth Fairy (Fox) | $60,022,256 |
|
| Jan 22 |
| 58 | Secretariat (Disney) | $59,713,955 |
|
| Oct 08 |
| 59 | Easy A (Sony / Screen Gems) | $58,401,464 |
|
| Sep 17 |
| 60 | Takers (Sony / Screen Gems) | $57,744,720 |
|
| Aug 27 |
| 61 | Legend of the Guardians: The Owls of Ga'Hoole (Warner Bros.) | $55,675,313 |
|
| Sep 24 |
| 62 | Life As We Know It (Warner Bros.) | $53,374,681 |
|
| Oct 08 |
| 63 | Letters to Juliet (Summit) | $53,032,453 |
|
| May 14 |
| 64 | Wall Street: Money Never Sleeps (Fox) | $52,474,616 |
|
| Sep 24 |
| 65 | Predators (Fox) | $52,000,688 |
|
| Jul 09 |
| 66 | Hot Tub Time Machine (MGM) | $50,288,000 |
|
| Mar 26 |
| 67 | Kick-Ass (Lionsgate) | $48,071,303 |
|
| Apr 16 |
| 68 | Killers (Lionsgate) | $47,059,963 |
|
| Jun 04 |
| 69 | Saw 3D (Lionsgate) | $45,710,178 |
|
| Oct 29 |
| 70 | Cop Out (Warner Bros.) | $44,875,000 |
|
| Feb 26 |
| 71 | Cats & Dogs: The Revenge of Kitty Galore (Warner Bros.) | $43,585,753 |
|
| Jul 30 |
| 72 | Edge of Darkness (Warner Bros.) | $43,313,294 |
|
| Jan 29 |
| 73 | Death at a Funeral (2010) (Sony / Screen Gems) | $42,739,347 |
|
| Apr 16 |
| 74 | Gulliver's Travels (2010) (Fox) | $42,714,645 |
|
| Dec 25 |
| 75 | Step Up 3D (Disney) | $42,400,223 |
|
| Aug 06 |
| 76 | The Last Exorcism (Lionsgate) | $41,034,350 |
|
| Aug 27 |
| 77 | Legion (Sony / Screen Gems) | $40,122,704 |
|
| Jan 22 |
| 78 | Burlesque (Sony / Screen Gems) | $39,440,655 |
|
| Nov 24 |
| 79 | The Crazies (Overture) | $39,123,589 |
|
| Feb 26 |
| 80 | For Colored Girls (Lionsgate) | $37,729,698 |
|
| Nov 05 |
| 81 | The Back-up Plan (CBS Films) | $37,490,007 |
|
| Apr 23 |
| 82 | Vampires Suck (Fox) | $36,661,504 |
|
| Aug 18 |
| 83 | The American (Focus) | $35,606,376 |
|
| Sep 01 |
| 84 | Green Zone (Universal) | $35,053,660 |
|
| Mar 12 |
| 85 | Marmaduke (Fox) | $33,644,788 |
|
| Jun 04 |
| 86 | Devil (Universal) | $33,601,190 |
|
| Sep 17 |
| 87 | Hereafter (Warner Bros.) | $32,746,941 |
|
| Oct 15 |
| 88 | When in Rome (Disney) | $32,669,056 |
|
| Jan 29 |
| 89 | Love and Other Drugs (Fox) | $32,367,005 |
|
| Nov 24 |
| 90 | She's Out of My League (Paramount) | $31,628,317 |
|
| Mar 12 |
| 91 | Scott Pilgrim vs. the World (Universal) | $31,524,275 |
|
| Aug 13 |
| 92 | Charlie St. Cloud (Universal) | $31,162,545 |
|
| Jul 30 |
| 93 | Morning Glory (2010) (Paramount) | $31,011,732 |
|
| Nov 10 |
| 94 | How Do You Know (Sony / Columbia) | $30,212,620 |
|
| Dec 17 |
| 95 | Daybreakers (Lionsgate) | $30,101,144 |
|
| Jan 08 |
| 96 | Nanny McPhee Returns (Universal) | $29,011,215 |
|
| Aug 20 |
| 97 | The Switch (2010) (Miramax) | $27,779,426 |
|
| Aug 20 |
| 98 | Brooklyn's Finest (Overture) | $27,163,593 |
|
| Mar 05 |
| 99 | Machete (Fox) | $26,593,646 |
|
| Sep 03 |
| 100 | Ramona and Beezus (Fox) | $26,167,00 |
|
| Jul 23 |
